Hydrogen bonding to aromatic pi systems

Nucleobase-fluorobenzene interactions: hydrogen bonding wins over pi stacking.

Energetics and cooperativity in three-center hydrogen bonding interactions. II. Intramolecular hydrogen bonding systems

Hydrogen bonding

molecules to evolve in the test tube. With the discovery of catalytic RNA, and advances in nucleic acid amplification techniques such as the polymerase chain reaction, it became possible to construct laboratory systems that allow the Darwinian evolution of functional RNA (and later DNA) molecules. This is not evolution based on natural selection, but rather directed evolution based on selection...

Cation-pi bonding and amino-aromatic interactions in the biomolecular recognition of substituted ammonium ligands.

Cation-pi bonds and amino-aromatic interactions are known to be important contributors to protein architecture and stability, and their role in ligand-protein interactions has also been reported. Many biologically active amines contain substituted ammonium moieties, and cation-pi bonding and amino-aromatic interactions often enable these molecules to associate with proteins. The role of organic...

Model systems for flavoenzyme activity: intramolecular self-assembly of a flavin derivative via hydrogen bonding and aromatic interactions.

We have synthesised a flavin derivative incorporating functionalities that promote intramolecular self-assembly via hydrogen bonding and aromatic interactions.